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Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of this compound are presented. The potency and selectivity of zoniporide may be due to the conformation that the… (More)
Zoniporide, an inhibitor of the Na+-H+ exchanger-1, was administered by continuous intravenous infusion to rats and dogs for up to 1 month. In 1-month studies, histological and functional changes were observed in select portions of the peripheral nervous system; however, these findings were not detected in 2-week studies at similar or higher doses. In the… (More)
About a rare benign tumor of the lung of a fifty-nine years old woman is reported. The possible relation to the group of the pulmonary hamartomas is discussed. The tumor was benoted as "Benign angiohamartomatous tumor".
A bronchogenic carcinoma was found in the sphere of the scar in a fifty-years-old man who suffered in 1945, 27 years before his death, from a pulmonary bullet wound caused by war influence. The histological examination furthermore disclosed considerable autoradiographic secured deposits of thorotrast in the carcinoma and scar sphere. One may suppose that in… (More)
The clinical signs as well as the pathological-anatomical and histological peculiarities of a case of fibrosarcoma of the right ventricle of the heart in a fifty-years-old women are described. Examining of all cases described in literature it becomes evident that when ascertaining the starting points, there is a fluent transition from the sarcoma of the… (More)