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The clinical, pathological, and neurochemical characteristics of a newly recognized inherited neurological disorder are reported. Lethargy and mental depression are early symptoms, followed by mild parkinsonism and progressive weight loss. Failure of automatic respiratory control develops and may result in sudden death. Advanced degeneration of the(More)
OBJECTIVE Zolmitriptan oral tablet is highly effective and well tolerated in the acute treatment of migraine with and without aura in adults. A nasal spray formulation has now been developed. The objective of this study was to compare the efficacy and tolerability of fixed doses of zolmitriptan administered via a nasal spray with placebo and zolmitriptan(More)
Somatization, anxiety, depression and personality disorders are common features of many patients with chronic headaches. Intensive short-term dynamic psychotherapy (ISTDP) is a brief therapy method developed specifically to treat patients with this cluster of somatic problems, symptoms and maladaptive behaviours through focusing on how the patient handles(More)
BACKGROUND Despite the availability of objective criteria, the diagnosis of migraine is thought to be missed frequently in primary practice. OBJECTIVE To determine the most important questions assisting in the clinical diagnosis of migraine headache. METHODS A cohort of 461 patients referred to headache specialists in Canada was assessed using a(More)
Five children with Down syndrome aged between 21 and 31 months, all of whom demonstrated habitual tongue protrusion, were randomly assigned to receive either oral-motor treatment or behavior modification. Tongue posture of all three children who received oral-motor treatment improved. For two of these the improvement leveled off after treatment had ended,(More)
OBJECTIVES To primarily assess the tolerability of zolmitriptan (Zomig) nasal spray 5mg in the long-term treatment of migraine, as well as determine efficacy and consistency of effect over time (up to 1 year). METHODS This randomised, double-blind-to-dose, parallel-group, multicentre study was designed as a two-phase, crossover trial with a total duration(More)
The relative effects of 'tone-reducing' (inhibitive) and standard casts on the gait patterns and functional motor activities of two children with cerebral palsy were examined in a repeated measures (single-subject) design. Both children's stride length improved in the tone-reducing casts, compared with standard casts, but there were no significant(More)