Allam Apparao

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BACKGROUND Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic syndrome. We (a) measured its level in persons with diabetes mellitus, (b) constructed a family tree of the enzyme using nucleotide sequences downloaded from NCBI. Butyrylcholinesterase was estimated colorimetrically using a commercially available kit (Randox Lab, UK).(More)
––The pathological functionality of an organism is done by protein-protein interaction. In protein-protein interaction the proteins bind to each other and the binding energy is not uniformly distributed. Much of the binding energy is caused by some critical amino acids comprising of a small fraction of interfaces. An attempt is in this paper to develop(More)
This chapter presents an extension of the authors' earlier work, where they showed that nucleotide/amino acid sequences related to insulin occurred in the plant kingdom. It was believed that plants did not have, nor did they need insulin, a protein hormone considered to be restricted to the animal kingdom. In the current study, the human insulin sequence(More)
Long QT syndrome (LQTS) is a congenital disorder characterized by a prolongation of the QT interval on ECG and a propensity to ventricular tachyarrhythmia, which may lead to syncope, cardiac arrest, or sudden death. LQTS is caused by mutations of the genes for cardiac potassium and sodium or calcium ion channels. 8 genes have been identified.LQT1 (KCNQ1),(More)
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