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Nova proteins are neuron-specific antigens targeted in paraneoplastic opsoclonus myoclonus ataxia (POMA), an autoimmune neurologic disease characterized by abnormal motor inhibition. Nova proteins regulate neuronal pre-messenger RNA splicing by directly binding to RNA. To identify Nova RNA targets, we developed a method to purify protein-RNA complexes from(More)
Alternative RNA splicing greatly increases proteome diversity and may thereby contribute to tissue-specific functions. We carried out genome-wide quantitative analysis of alternative splicing using a custom Affymetrix microarray to assess the role of the neuronal splicing factor Nova in the brain. We used a stringent algorithm to identify 591 exons that(More)
Many people incur costs to reward strangers who have been kind to others. Theoretical and experimental evidence suggests that such "indirect rewarding" sustains cooperation between unrelated humans. Its emergence is surprising, because rewarders incur costs but receive no immediate benefits. It can prevail in the long run only if rewarders earn higher(More)
This paper reports results from a laboratory experiment on network formation among heterogeneous agents. The experimental design extends the Bala-Goyal (2000) model of network formation with decay and two-way flow of benefits by introducing agents with lower linking costs or higher benefits to others. Furthermore, agents’ types may be common knowledge or(More)
A finitely repeated multi-player prisoner’s dilemma game has a unique, defective Nash equilibrium when played in a fixed group or on a fixed network. This paper shows that, in contrast, cooperation can be achieved in a subgame-perfect Nash equilibrium of a finitely repeated prisoner’s dilemma game when played over an endogenously formed network. The(More)
This paper investigates infrastructure investment in markets where regulation is subject to varying degrees of manipulation by elected politicians. Based on a model of price regulation in a market with increasing demand and long-term returns on investment we construct a multi-period game between a service provider, consumers with voting rights and elected(More)
This note develops a modelling approach for wireless networks driven by uid traÆc models. Introducing traÆc sets that follow movement of subscribers, the wireless network with time-varying rates is transformed into a stationary network at these traÆc sets, which yields that the distribution of calls over the cells of the network depends on the call length(More)
, 1701 (2009); 326 Science et al. Aljaz Ule, Strangers Indirect Punishment and Generosity Toward www.sciencemag.org (this information is current as of December 29, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/326/5960/1701 version of this article at: including high-resolution(More)
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