Alistair Simpson

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BACKGROUND Both tissue hypoxia in vitro, and whole-body hypoxia in vivo, have been found to promote the release of reactive oxygen species (ROS) that are potentially damaging to the cardiovascular system. Antioxidant systems protect against oxidative damage by ROS and may exhibit some degree of responsiveness to oxidative stimuli. Production of urate, a(More)
Ventilatory control undergoes profound changes on ascent to high altitude. We hypothesized that the fall in citric acid cough threshold seen on ascent to altitude is mediated by changes in the central control of cough and would parallel changes in central ventilatory control assessed by the hypercapnic ventilatory response (HCVR). Twenty-five healthy(More)
BACKGROUND According to recommendations, intraabdominal pressure should be monitored every 8 hours for patients at high risk of abdominal compartment syndrome. Continuous intraabdominal pressure monitoring may be valuable for these patients. METHODS For 15 patients undergoing laparoscopic surgery, a pressure monitor was introduced after formation of(More)
PURPOSE To demonstrate the influence of radiographic positioning on the assessment of stent-graft migration using plain radiographs following endovascular abdominal aortic aneurysm repair. METHODS Equations were derived to correct for artifactual stent-graft migration introduced by geometric distortion due to variations in positioning between radiographs(More)
Monitoring parent drug cyclosporine (CsA) concentrations in whole blood has been facilitated by the introduction of automated nonisotopic immunoassays [fluorescence polarization monoclonal whole blood assay (FPIA), EMIT Cyclosporine Assay]. The latter assay currently has a defined application only for Cobas Mira Chemistry Systems. The purpose of our work(More)
OBJECTIVES To investigate the effect of Antarctic residence on energy dynamics and aerobic fitness over the course of a year in over-wintering personnel. STUDY DESIGN A prospective longitudinal observational study. METHODS A convenience sample of personnel over-wintering at Rothera Research Station in Antarctica was studied. Body weight, body fat, food(More)
Aerobic bacterial populations were studied on the distal hair coat and at the skin surface of the shoulder, rump and abdomen of 10 healthy dogs. Coagulase negative staphylococci (CNS) were more frequently isolated from the hair than the skin at the shoulder and rump. There was no difference in the isolation rate of coagulase positive staphylococci (CPS)(More)
SUMMARY A group of 143 compounds, consisting mainly of substituted purines, was tested as potential inhibitors of ribonucleoside metabolism; the screening system was the synthesis of inosine, in vitro, by erythrocytes from humans. A series of purine derivatives with particular substituent groups at positions 6 and 9 inhibited inosine synthesis by intact(More)