Alison Walling

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The MouseBook (http://www.mousebook.org) databases and web portal provide access to information about mutant mouse lines held as live or cryopreserved stocks at MRC Harwell. The MouseBook portal integrates curated information from the MRC Harwell stock resource, and other Harwell databases, with information from external data resources to provide(More)
Two large-scale phenotyping efforts, the European Mouse Disease Clinic (EUMODIC) and the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during the late 2000s with the aim to deliver a comprehensive assessment of phenotypes or to screen for robust indicators of diseases in mouse mutants. They both took advantage of available(More)
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline(More)
Understanding the functions encoded in the mouse genome will be central to an understanding of the genetic basis of human disease. To achieve this it will be essential to be able to characterize the phenotypic consequences of variation and alterations in individual genes. Data on the phenotypes of mouse strains are currently held in a number of different(More)
Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we combine low-coverage (0.15×) sequencing with a new method to impute the ancestral haplotype space in 1,887(More)
* The Mouse Phenotype Database Integration Consortium currently comprises: John M. Hancock, Niels C. Adams, Vassilis Aidinis, Andrew Blake, Judith A. Blake, Molly Bogue, Steve D.M. Brown, Elissa Chesler, Duncan Davidson, Christopher Duran, Janan T. Eppig, Valérie Gailus-Durner, Hilary Gates, Georgios V. Gkoutos, Simon Greenaway, Martin Hrabé de Angelis,(More)
Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually tracked and subjected to phenotyping procedures according to a standardised schedule. All these efforts are typically organised in overlapping projects, running in(More)
  • Mary Rudie, Barneby Research, +92 authors Seryl Kushner Dean
  • 2007
ACKNOWLEDGMENTS The College of Arts and Science wishes to thank the contributors to the Dean's Undergraduate Research Fund for their generosity in establishing the following scholarships to support undergraduate research projects: Located at the center of a premier research institution, the College of Arts and Science at New York University has the(More)
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