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PURPOSE Dinaciclib inhibits cyclin-dependent kinases 1, 2, 5, and 9 with a better therapeutic index than flavopiridol in preclinical studies. This study assessed the activity of dinaciclib in acute leukemia both in the clinic and in vitro. METHODS Adults with relapsed/refractory acute myeloid leukemia (n = 14) and acute lymphoid leukemia (n = 6) were(More)
  • Carrol Gamble, Louise Dudley, Alison Allam, Philip Bell, Heather Goodare, Bec Hanley +4 others
  • 2014
BACKGROUND Randomised controlled trials (RCTs) are considered particularly likely to benefit from patient and public involvement (PPI). Decisions made by professional researchers at the outset may go on to have a significant impact on the potential for PPI contributions. OBJECTIVE To increase knowledge of PPI within the early development of RCTs by(More)
Decitabine (DAC) is used for treatment of patients with myelodysplastic syndromes and acute myeloid leukemia (AML). Following cellular uptake, DAC is activated to DAC-triphosphate (TP) and incorporated into DNA. Once incorporated into the DNA, DAC-TP binds and inactivates DNA methyltransferases (DNMTs), thereby leading to hypomethylation and re-expression(More)
We developed a locative fiction application called nan0sphere and deployed it on the UCLA campus. This application presents an interactive narrative to users working in a group as they move around the campus. Based on each user's current location, previously visited locations, actions taken, and on the similar attributes of other users in the same group,(More)
PURPOSE The aim of this study was to identify the supportive care needs and unmet needs of women with breast cancer (BC) in rural Scotland. METHODS In 2013, a survey of supportive care needs of rural women with BC was conducted using the short-form Supportive Care Needs Survey (SCNS-SF34). Semi-structured interviews were subsequently conducted with a(More)
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