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OBJECTIVE To test the hypothesis that white matter integrity, as measured by diffusion tensor and magnetization transfer MRI is significantly associated with cognitive ability measured in youth and old age. METHODS Forty, nondemented, surviving participants of the Scottish Mental Survey of 1932 underwent brain MRI and a battery of psychometric tests(More)
DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age. Here we test whether differences between people’s chronological ages and estimated ages, DNA methylation age, predict all-cause mortality(More)
This cohort profile describes the origins, tracing, recruitment, testing and follow-up of the University of Edinburgh-based Lothian Birth Cohorts of 1921 (LBC1921; N = 550) and 1936 (LBC1936; N = 1091). The participants undertook a general intelligence test at age 11 years and were recruited for these cohorts at mean ages of 79 (LBC1921) and 70 (LBC1936).(More)
BACKGROUND The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength(More)
The National Adult Reading Test (NART), used to estimate premorbid mental ability, involves pronunciation of irregular words. The authors demonstrate that, after controlling for age 11 IQ test scores, mean NART scores do not differ in people with and without dementia. The correlation between age 11 IQ and NART scores at about age 80 was similar in the(More)
GoldbergÕs (2001) IPIP Big-Five personality factor markers currently lack validating evidence. The structure of the 50-item IPIP was examined in three different adult samples (total N = 906), in each case justifying a 5-factor solution, with only minor discrepancies. Age differences were comparable to previous findings using other inventories. One sample (N(More)
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes:(More)
AIMS To examine the relation between birth weight and cognitive function at age 11 years, and to examine whether this relation is independent of social class. METHODS Retrospective cohort study based on birth records from 1921 and cognitive function measured while at school at age 11 in 1932. Subjects were 985 live singletons born in the Edinburgh Royal(More)
General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53,949) in which the(More)
The associations of childhood intelligence and dependability with adult mortality were examined in 1,181 people who were representative of the Scottish nation. Participants were born in 1936 and were followed for mortality from 1968 through early 2003. Higher intelligence and greater dependability were independent, significant predictors of lower mortality:(More)