Alison Mackenzie

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Vaccination has been proposed for the prevention of disease due to enterohemorrhagic Escherichia coli (EHEC), but the immune response following human infection, including the choice of potential antigens, has not been well characterized. To study this, sera were obtained from five pediatric patients with acute diarrhea caused by E. coli O157:H7 0, 8, and 60(More)
BACKGROUND Many people with asthma tolerate symptoms and lifestyle limitations unnecessarily by not utilizing proven therapies. Better support for self-management is known to improve asthma control, and increasingly the Internet and other digital media are being used to deliver that support. OBJECTIVE Our goal was to summarize current knowledge, evidenced(More)
BACKGROUND Musculoskeletal disorders are common and costly disorders to workers compensation and motor accident insurance systems and are a leading contributor to the burden of ill-health. In Australia, vocational rehabilitation is provided to workers to assist them to stay in, or return to work. Self-management training may be an innovative addition to(More)
BACKGROUND Understanding the risk of mortality during the 1918-1919 influenza pandemic could inform preparations for a future pandemic. METHODS Prospectively collected demographic, hospitalization, and death data from all individuals who served in the Australian Imperial Force from 1914 through 1919 in Europe and the Middle East were abstracted from(More)
BACKGROUND The anti-inflammatory effects of the selective phosphodiesterase (PDE) inhibitors cilostazol (PDE 3), RO 20-1724 (PDE 4) and sildenafil (PDE 5) were examined in a murine model of allergic asthma. These compounds were used alone and in combination to determine any potential synergism, with dexamethasone included as a positive control. METHODS(More)
BACKGROUND During the 1918-1919 influenza pandemic, nurses and physicians were intensively exposed to the pandemic A/H1N1 strain. There are few published summaries of the mortality experiences of nurses and physicians during the pandemic. METHODS Mortality records from U.S. and British Armies during the First World War and obituary notices in national(More)
Despite significant advances in medical therapy, most patients with pulmonary arterial hypertension (PAH) remain symptomatic on treatment [1]. The recently published UK PAH national audit 2014 [2] demonstrates a 65% rate of failure of monotherapy at 2 years. New treatment strategies are therefore essential to improve morbidity and, if possible, mortality.(More)
INTRODUCTION There are few studies on the experiences of spouses of military members, with most focused on adverse impacts of deployment. Responses to an open-ended question in a survey of spouses' health and wellbeing enabled access to perceptions and insights on a broad range of topics. The objective of this investigation was to examine how respondents(More)
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