Alison M. Laffan

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Aging is associated with an earlier timing of circadian rhythms and a shorter phase angle between wake time and the timing of melatonin secretion or the core body temperature nadir. Light has a phase-dependent effect on the circadian pacemaker, and modifications of habitual light exposure in older people could contribute to a change in the timing of(More)
STUDY OBJECTIVES Sleep continuity is commonly assessed with polysomnographic measures such as sleep efficiency, sleep stage percentages, and the arousal index. The aim of this study was to examine whether the transition rate between different sleep stages could be used as an index of sleep continuity to predict self-reported sleep quality independent of(More)
STUDY OBJECTIVES We investigated the association of HIV infection and highly active antiretroviral therapy (HAART) with sleep disordered breathing (SDB), fatigue, and sleepiness. METHODS HIV-uninfected men (HIV-; n = 60), HIV-infected men using HAART (HIV+/HAART+; n = 58), and HIV-infected men not using HAART (HIV+/HAART-; n = 41) recruited from two sites(More)
Antibiotic-associated diarrhoea (AAD) is a common cause of morbidity and mortality. Older individuals in long-term care facilities are particularly vulnerable due to multisystem illnesses and the prevailing conditions for nosocomial infections. Lactoferrin, an antimicrobial protein in human breastmilk, was tested to determine whether it would prevent or(More)
The authors wish to thank the following individuals for their contributions to the development and review of the guide: Introduction The passage of health care reform and current efforts in payment reform signal a significant transformation of the United States health care system. An entire set of structures is being developed to facilitate increased access(More)
Since the discovery of EEG almost 150 years ago, it remains a valuable tool in the work-up of suspected epilepsy. However, EEG is not without its limitations and an understanding of the indications and how to interpret the findings are essential to avoid over-reliance on an investigation which can lead to misdiagnosis if inappropriately used. We conducted a(More)
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