Alison Joy Butt

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Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis.

Natalie L Harvey, Alison Joy Butt, S. K. Nandha Kumar
The Journal of biological chemistry
1997

The ICE/CED-3 family of proteases (caspases) play a central role in the execution phase of apoptosis. These proteases are synthesised as precursor molecules that require processing at specific… (More)

The IGF axis and programmed cell death.

Alison Joy Butt, Sue M. Firth, R. C. Baxter
Immunology and cell biology
1999

Insulin-like growth factors (IGF) are mitogenic peptides that have been implicated as positive regulators of cellular proliferation. In recent years, several studies have suggested an additional role… (More)

Evaluation of the impact of National Breast Cancer Foundation-funded research.

Claire Donovan, Linda Butler, Alison Joy Butt, Teresa H. Jones, Steve Hanney
The Medical journal of Australia
2014

OBJECTIVE To evaluate the impact of the National Breast Cancer Foundation's (NBCF's) research investment. DESIGN AND PARTICIPANTS Surveys based on the Payback Framework were sent to chief… (More)

Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo.

Alison Joy Butt, Kristie A Dickson, Fiona A McDougall, Robert Baxter
The Journal of biological chemistry
2003

The role of insulin-like growth factor-binding protein (IGFBP)-5 in human breast cancer cell growth is unclear. We determined the effects of IGFBP-5 expression on the growth of human breast cancer… (More)

Identification of Functional Networks of Estrogen- and c-Myc-Responsive Genes and Their Relationship to Response to Tamoxifen Therapy in Breast Cancer

Elizabeth A. Musgrove, C. Marcelo Sergio, +11 authors R. Sutherland
PloS one
2008

BACKGROUND Estrogen is a pivotal regulator of cell proliferation in the normal breast and breast cancer. Endocrine therapies targeting the estrogen receptor are effective in breast cancer, but their… (More)

Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells.

Alison Joy Butt, Sue M. Firth, M. A. King, R. C. Baxter
The Journal of biological chemistry
2000

We report that transfection of insulin-like growth factor-binding protein-3 (IGFBP-3) cDNA in human breast cancer cell lines expressing either mutant p53 (T47D) or wild-type p53 (MCF-7) induces… (More)

A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells.

Alison Joy Butt, Caroline Roberts, +8 authors R. Sutherland
Molecular cancer therapeutics
2006

Phytochemicals have provided an abundant and effective source of therapeutics for the treatment of cancer. Here we describe the characterization of a novel plant toxin, persin, with in vivo activity… (More)

Identification of downstream targets of estrogen and c-myc in breast cancer cells.

Elizabeth A. Musgrove, C. Marcelo Sergio, +7 authors R. Sutherland
Advances in experimental medicine and biology
2008

Estrogen (E) plays a pivotal regulatory role in the control of cell proliferation in the normal breast and breast cancer (BC). To identify genes with likely roles in proliferation control that are… (More)

Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism.

Caroline Roberts, Ebru Gurisik, Trevor J Biden, R. Sutherland, Alison Joy Butt
Molecular cancer therapeutics
2007

Phytochemicals have provided an abundant source of novel therapeutics for the treatment of human cancers. We have previously described a novel plant toxin, persin, derived from avocado leaves, which… (More)

Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.

Alison Joy Butt, Catriona M McNeil, Elizabeth A. Musgrove, R. Sutherland
Endocrine-related cancer
2005

Antioestrogen therapy is a highly effective treatment for patients with oestrogen-receptor (ER)-positive breast cancer, emphasising the central role of oestrogen action in the development and… (More)

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