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OBJECTIVES To explore why cancer patients do not want or seek information about their condition beyond that volunteered by their physicians at times during their illness. DESIGN Qualitative study based on in-depth interviews. SETTING Outpatient oncology clinics at a London cancer centre. PARTICIPANTS 17 patients with cancer diagnosed in previous 6(More)
During development of the central nervous system, the transition from progenitor maintenance to differentiation is directly triggered by a lengthening of the cell cycle that occurs as development progresses. However, the mechanistic basis of this regulation is unknown. The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of(More)
Acknowledgements The research team would like to acknowledge the significant input made to this project by several colleagues at NFER. Sincere thanks are due to the staff of the NFER Library, particularly Lynne Harris, Alison Jones and Chris Taylor. Special thanks are also due to the Project Secretary, Susan Stoddart, who finalised the report and provided(More)
BACKGROUND Few meta-analyses of randomised trials assess the quality of the studies included. Yet there is increasing evidence that trial quality can affect estimates of intervention efficacy. We investigated whether different methods of quality assessment provide different estimates of intervention efficacy evaluated in randomised controlled trials (RCTs).(More)
Inhibitory interneurons play important roles in neuronal circuits, but the synaptic mechanisms that regulate excitatory input onto interneurons remain to be fully understood. We show that ATP-gated presynaptic P2X2 channels facilitate excitatory transmission onto stratum radiatum interneurons but not onto CA1 pyramidal neurons. ATP released endogenously(More)
Prolonged chewing of food can reduce meal intake. However, whether prolonged chewing influences intake at a subsequent eating occasion is unknown. We hypothesised that chewing each mouthful for 30s would reduce afternoon snack intake more than (a) an habitual chewing control condition, and (b) an habitual chewing condition with a pauses in between each(More)
This paper evaluates automatic extraction of ten named entity classes from a 19th century newspaper, the Civil War years of the <i>Richmond Times Dispatch</i>, digitized with IMLS support by the University of Richmond. This paper analyzes success with ten categories of entities prominent in these newspapers and the particular problems that these classes of(More)
search Council of Canada. We are grateful to the students and professors for their cooperation and participation and to three anonymous reviewers for their insightful comments on an earlier draft of this article. The purpose of the present study was to explore the influence of individual and contextual factors on students' assessments of their own(More)
Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD, while simultaneously controlling progenitor maintenance non-cell-autonomously by upregulating Delta expression and Notch signalling. Reduction in Cdk-dependent multisite phosphorylation of Ngn2 enhances its promoter binding(More)