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Peribronchial inflammation contributes to the pathophysiology of allergic asthma. In many vascular beds, adhesive interactions between leukocytes and the endothelial surface initiate the recruitment of circulating cells. Previous studies using OVA-induced airway hyperreactivity indicated that P-selectin, a member of the selectin family expressed by(More)
Epilepsy is relatively uncommon in patients with Neurofibromatosis Type 1 (NF1) and seizures are usually well controlled with antiepileptic treatment. However, pharmacoresistance has been reported in patients with NF1 and MRI evidence of malformations of cortical development or glioneuronal tumours. Available information on epilepsy surgery in NF1 is(More)
There has been a spectacular rise in the global prevalence of type 2 diabetes mellitus and cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The objective of the study was to investigate ventricular myocyte shortening, intracellular Ca2+ signalling and expression of genes encoding cardiac muscle proteins in(More)
Fibrogenic growth factors can force epithelial cells of the lung, kidney and liver to undergo transition to a mesenchymal phenotype – a process known as epithelial to mesenchymal transition (EMT) 1. EMT contributes to fibrosis in these organs, and can be inhibited/reversed in animal models 2. EMT has not been shown in fibrotic skin disorders. We(More)
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