Alison J. Eastwood

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OBJECTIVES To survey the frequency of use of indirect comparisons in systematic reviews and evaluate the methods used in their analysis and interpretation. Also to identify alternative statistical approaches for the analysis of indirect comparisons, to assess the properties of different statistical methods used for performing indirect comparisons and to(More)
OBJECTIVE To investigate basic assumptions and other methodological problems in the application of indirect comparison in systematic reviews of competing healthcare interventions. DESIGN Survey of published systematic reviews. Inclusion criteria Systematic reviews published between 2000 and 2007 in which an indirect approach had been explicitly used. (More)
OBJECTIVES To review, and to develop further, the methods used to assess and to increase the generalisability of economic evaluation studies. DATA SOURCES Electronic databases. REVIEW METHODS Methodological studies relating to economic evaluation in healthcare were searched. This included electronic searches of a range of databases, including(More)
OBJECTIVE To investigate the barriers, modifiers, and benefits involved in participating in randomized controlled trials of cancer therapies as perceived by health care providers and patients. STUDY DESIGN AND SETTING We conducted a systematic review of the literature to identify published and unpublished studies in any language using electronic databases(More)
BACKGROUND Currently there is a wide range of health status measures that aim to assess general health status in people with cognitive impairment. However, the validity and/or applicability to this patient group are largely unknown. This has implications for the assessment of treatment outcomes and rehabilitation, for prognostic purposes, for planning(More)
OBJECTIVE Publication bias threatens the validity of published research, although this topic has received little attention in psychiatry. The purpose of this article is to produce a systematic overview of the causes and consequences of publication bias and to summarize the available methods with which it is detected and corrected. METHOD Empirical(More)
BACKGROUND Depression is the most common mental disorder in community settings and a major cause of disability across the world. The objective of treatment is to achieve remission or at least adequate control of depressive symptoms; however, even after successful treatment, the risk of relapse after remission is significant. Although the effectiveness of(More)
Background Concentration of the provision of hospital services is sometimes seen as a way to reduce costs and improve the quality and efficiency of care. This paper, based on an issue of Effective Health Care Vol 2, No 8 summarises the results of systematic reviews carried out at the University of York to assess research into the possible relation between(More)
BACKGROUND Palliative radiotherapy (RT) to the chest is often used in patients with lung cancer, but RT regimens are more often based on tradition than research results. OBJECTIVES To discover the most effective and least toxic regimens of palliative RT, and whether higher doses increase survival. SEARCH STRATEGY Electronic databases, reference lists,(More)