Alison G Hoppin

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The objective of this study is to update evidence-based best practice guidelines for pediatric/adolescent weight loss surgery (WLS). We performed a systematic search of English-language literature on WLS and pediatric, adolescent, gastric bypass, laparoscopic gastric banding, and extreme obesity published between April 2004 and May 2007 in PubMed, MEDLINE,(More)
Gastrointestinal weight-loss surgery (GIWLS) is currently the most effective treatment for severe obesity, with Roux en-Y gastric bypass (RYGB) among the best of the available surgical options. Despite its widespread clinical use, the mechanisms by which RYGB induces its profound weight loss remain largely unknown. This procedure effects weight loss by(More)
BACKGROUND Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy. OBJECTIVE To see whether sibutramine reduced weight more than placebo in obese adolescents who were receiving a behavior therapy program. DESIGN 12-month, 3:1 randomized, double-blind trial conducted from July 2000 to February 2002. (More)
The liver is responsible for the clearance and metabolism of unconjugated bilirubin, the hydrophobic end-product of heme catabolism. Although several putative bilirubin transporters have been described, it has been alternatively proposed that bilirubin enters the hepatocyte by passive diffusion through the plasma membrane. In order to elucidate the(More)
BACKGROUND/OBJECTIVE We evaluated the prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in 27 adolescents referred for weight loss surgery (WLS). RESULTS On biopsy, 18 patients (66.7%) had NAFLD, and of those, 10 (37.0%) had NASH and 11 (40.7%) had fibrosis. Insulin, HbA1C and homeostatic model assessment of(More)
INCIDENCE — Clinically significant cerebral edema occurs in approximately 1 percent of episodes of diabetic ketoacidosis in children and has a mortality rate of 20 to 90 percent; 50 to 80 percent of diabetes-related deaths are caused by cerebral edema [1-3]. Overall mortality rates for diabetic ketoacidosis (DKA) in children range from 0.15 to 0.51 percent(More)
BACKGROUND Pediatric inflammatory bowel disease is often associated with growth failure and inadequate energy intake. Although several circulating cytokines are known to be elevated in inflammatory bowel disease, the mechanism for the related anorexia has not been described. Leptin is a newly recognized circulating protein that is an important regulator of(More)