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High cardiorespiratory fitness (CRF) is an important protective factor reducing the risk of cardiac-related disability and mortality. Recent research suggests that high CRF also has protective effects on the brain's macrostructure and functional response. However, little is known about the potential relationship between CRF and the brain's white matter (WM)(More)
Sex-based differences in the prevalence and presentation of arterial and venous thrombosis exist, and emerging data indicate that men and women do not accrue equal benefit from antithrombotic therapy. Sex hormones alter procoagulant protein expression and the function of blood and vascular cells. Sex-based differences in platelet function have been(More)
The goal of the meeting was for the participants to react to the CRESST research plan for operationalizing academic language and provide feedback and guidance for refining the plan. The participants at the meeting brought a wide range of expertise to bear on the issue and were articulate in emphasizing the critical nature of the work given the current(More)
The findings and opinions expressed in this report do not reflect the positions or policies of the iii ACKNOWLEDGMENTS First, we wish to acknowledge the Office of Educational Research and Improvement (OERI) * and the Office of Bilingual Education and Minority Languages Affairs (OBEMLA) in Washington, DC, for recognizing the need to investigate issues of(More)
AIMS Digoxin is frequently used for rate control of atrial fibrillation (AF). It has, however, been associated with increased mortality. It remains unclear whether digoxin itself is responsible for the increased mortality (toxic drug effect) or whether it is prescribed to sicker patients with inherently higher mortality due to comorbidities. The goal of our(More)
The subclass pattern of red cell bound IgG autoantibody was studied in 304 patients on 426 occasions. Subclass interrelationships with time, other cell bound immunoglobulins (IgM, IgA), amount of bound IgG and serum haptoglobin levels were investigated using population proportions; because of the multiple statistical tests, P less than 0.01 was required for(More)
Salivary diagnostics is an emerging field that has progressed through several important developments in the past decade, including the publication of the human salivary proteome and the infusion of federal funds to integrate nanotechnologies and microfluidic engineering concepts into developing compact point-of-care devices for rapid analysis of this(More)
Takotsubo cardiomyopathy is a stress-related cardiomyopathy that mimics acute myocardial infarction. However, it is frequently without obstructive coronary artery disease and is mainly seen in postmenopausal women after an emotional or physiological event. In rare cases, it favours the formation of intracardiac mural thrombus and subsequent cardioembolic(More)
Acknowledgments Many people generously contributed to the development of this study. We would like to thank all the researchers—faculty, staff, and students—who participated in and informed the study. We are especially grateful to Joan Herman for her insightful comments and advice. Frances Butler and Alison Bailey advised on the choice of the study's(More)
In the broadest context, biological markers, or biomarkers, are molecules that characterize a biological system or process. In the setting of cardiovascular disease, a number of biomarkers have become an integral part of diagnostic and risk stratification strategies. In this review, we will discuss classic and emerging biomarkers of cardiovascular disease(More)