Alisdair J. MacDonald

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The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to be useful in differentiating different(More)
Background Intramyocellular lipids are an important source of fuel for mitochondrial fat oxidation and play an important role in intramuscular lipid homeostasis. We hypothesised that due to the phenotype associated with cancer cachexia, there would exist an association between increasing weight loss and the number/size of intramyocel-lular lipid droplets.(More)
OBJECTIVE To describe the clinical features of reversible cognitive dysfunction. DESIGN Prospective cohort study. SETTING Acute geriatric inpatient units. PATIENTS A random sample of consecutive acute admissions of patients over the age of 65 (N = 80). MAIN MEASUREMENTS Serial assessments of mental state and cognitive function and observational(More)
OBJECTIVE To study performance of DSM-III-R, ICD-10 and CAMDEX diagnoses of delirium as predictors of improvement in mental state in survivors, and to develop a brief rating scale which will predict reversibility of cognitive dysfunction. DESIGN Prospective cohort study. SETTING Acute geriatric inpatient units. PATIENTS A random sample of consecutive(More)
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