Alireza Mirghasemi

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Osteosarcoma is the most common type of bone cancer in children and adolescents. MicroRNAs (miRNAs) play important roles in the development, differentiation, and function of different cell types and in the pathogenesis of various human diseases. miRNAs are differentially expressed in normal and cancer cells. The investigation of miRNA expression between(More)
MiRNAs play crucial roles in development of cancer. However, the underlying mechanisms of miRNAs in osteosarcoma (OS) are poorly understood. This study is aimed to investigate the clinical importance of miR-125b and miR-300 expression in OS tissue samples using real-time PCR. Total RNA was purified from samples and noncancerous bone tissues and then(More)
Increasing evidence has confirmed that dysregulation of microRNAs (miRNAs) can contribute to the progression and metastasis of human tumors. Chondrosarcoma is the most common primary malignant bone tumor in adults and has no effective systemic treatment, and patients with this disease have poor survival. Thus, it is important to find new diagnostic markers(More)
MicroRNAs (miRNAs) play key roles in cancer development and progression. The purpose of the present study was to determine the expression levels of miR-133a and miR-539 in osteosarcoma patients and to further investigate the clinicopathological, and prognostic value of these miRNAs. The expression levels of miR-133a and miR-539 were determined by qRT-PCR.(More)
of irregularities in authorship, there is strong reason to believe that the peer review process was compromised and the article is showing similarities with the following article which was submitted within a close timeframe: Afshin Taheriazam, Downregulation of miR-133b/miR-503 acts as efficient prognostic and diagnostic factors in patients with(More)
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