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Running Title: Chemopreventive activities of geranylgeraniol and β-ionone. Abstract Chemopreventive activities of the isoprenoids geranylgeraniol (GGO) and β-ionone (BI) were evaluated during initial phases of hepatocarcinogenesis. Rats received daily during 7 weeks 8 or 16 mg/100 g body weight GGO (GGO8 and GGO16 groups) or BI (BI8 and BI16 groups), or(More)
Chemopreventive activities of the isoprenoids geranyl-geraniol (GGO) and b-ionone (BI) were evaluated during initial phases of hepatocarcinogenesis. Rats received 8 or 16 mg/100 g body wt GGO (GGO8 and GGO16 groups) or BI (BI8 and BI16 groups), or only corn oil (CO group, controls) daily for 7 weeks. Incidence (%) and the mean number of visible hepatocyte(More)
Furan is a significant food contaminant and a potent hepatotoxicant and rodent liver carcinogen. The carcinogenic effect of furan has been attributed to genotoxic and non-genotoxic, including epigenetic, changes in the liver; however, the mechanisms of the furan-induced liver tumorigenicity are still unclear. The goal of the present study was to investigate(More)
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