Aline Meyer Rosa

Learn More
Procedures for the preparation of high- and low-salt Triton insoluble cytoskeletal fractions from rat brain suitable for studying in vitro phosphorylation by endogenous kinases and phosphatases are described. The high-salt Triton insoluble cytoskeletal fraction is enriched in neurofilament subunits (NF-H, NF-M and NF-L), vimentin and glial fibrillary acidic(More)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to motor neuron loss. Fused in sarcoma (FUS) protein carrying ALS-associated mutations localizes to stress granules and causes their coalescence into larger aggregates. Here we show that Pur-alpha physically interacts with mutated FUS in an RNA-dependent manner. Pur-alpha(More)
In the current study we investigated the effect of the branched-chain alpha-keto acids (BCKA) co-ketoisocaproic (KIC), alpha-keto-beta-methylvaleric (KMV), and alpha-ketoisovaleric (KIV) acids, which accumulate in maple syrup urine disease (MSUD), on the in vitro uptake of [3H]glutamate by cerebral cortical slices from rats aged 9, 21, and 60 days of life.(More)
  • 2011
Resumo A isquemia intestinal é um problema clínico que pode levar a alterações morfológicas nos neurônios entéricos. Esse estudo analisou os efeitos da isquemia/reperfusão (I/R-i) em neurônios imunorreativos ao receptor P2X 2 e as classes de neurônios no plexo mioentérico do íleo de ratos. A isquemia intestinal foi obtida pela oclusão da artéria mesentérica(More)
  • 1