Learn More
Quail-to-chick grafting experiments performed during the third day of incubation demonstrate that somites can contribute to limb development. In orthotopic recombinations, migrating cells originating from the grafted unsegmented or segmented somitic mesoderm adjacent to the wing or leg field end up in the musculature respectively of the wing or the leg,(More)
The aim of this study is to test the ability of the intrinsic wing musculature to develop in the absence of somitic mesoderm. The experiments were performed on 2- to 2.5-day chick embryos either by replacing the somitic mesoderm adjacent to the wing field with a piece of 9-day chick embryonic midgut or by destroying, through local X-irradiation, not only(More)
If the somitic mesoderm of a 2-day chick embryo is destroyed by X-irradiation, the adjacent limb develops with a normal pattern of connective tissues, but is devoid of muscle. The innervation of muscleless wings produced in this way was examined in silver-stained whole mounts, fixed 3 to 8 days later. The main nerve trunks and their cutaneous branches(More)
BACKGROUND Epidemiological studies emphasize the possible role of persistent organic pollutants (POPs) in obesity and the metabolic syndrome. These pollutants are stored in adipose tissue (AT). OBJECTIVES Our aim was to study the effects of POPs on human adipose cells and rodent AT. METHODS Using human multipotent adipose-derived stem cells, we carried(More)
The Aryl hydrocarbon Receptor or AhR, a ligand-activated transcription factor, is known to mediate the toxic and carcinogenic effects of various environmental pollutants such as 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Recent studies in Caenorhabditis elegans and Drosophila melanogaster show that the orthologs of the AhR are expressed exclusively in(More)
The rapid development of the silk glands of Bombyx mori during the last larval instar shows two phases. During the first 4 days, in both the middle and posterior parts of the silk glands, the ribosomal machinery is assembled and the synthesis of housekeeping proteins starts. During the second phase (the last 4 days), the middle part of the gland synthesis(More)
Number of experiments of our group (Chevallier et al., 1976, 1977; Kieny et al., 1979; Kieny and Chevallier, 1980; Mauger and Kieny, 1980 a, b) have led to the idea that the somite-derived cells which invade the somatopleural limb mesoderm constitute a distinct myogenic cell lineage. An idea opposite to the lineage view, namely that of the multipotency of(More)
The nuclear specificity of 12 day embryonic skeletal muscle cells has been studied in ectopic limbs that developed after implantation of quail limb somatopleural mesoderm into chick hosts. In eleven cases, the nuclearity of the myotubes was homospecifically of chick type. In the remnant eight cases, the musculature was heterospecific, the myotubes being(More)