Alina Yu. Babenko

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The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) is an important negative regulator of signal transduction through the T-cell receptors (TCR). Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic(More)
Patients with thyreotoxicosis have variable clinical manifestations and various degree of cardiomyopathy which severity depends on many factors. Last years the genetic factors predicting development and clinical features of thyrotoxic symptoms and thyreotoxic cardiomyopathy became more evident. It is known, that production of T3 in various tissues including(More)
1.1 Thyrotoxicosis and thyrotoxic cardiomyopathy – Current state Thyrotoxicosis is a common syndrome, and according to the Wickham Survey its prevalence is 2% among women and 0.2% in men in the areas with normal iodine consumption. Over the 20-year follow-up the incidence of thyrotoxicosis was 0.8:1000 in women and 0.6:1000 in men (Bird et al,1977).(More)
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