Alina V Aleksandrova

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We studied the effects of DMSO and fibroblasts during HepaRG cell spheroid formation and conditions of their subsequent culturing on the levels of mRNA of the major cytochromes P450. A protocol of spheroid formation from differentiated HepaRG cells and their culturing in serum- and DMSO-free medium is developed.
Microscopic, mostly imperfect, fungi play an important role in the degradation of the organic matter, especially of lignin, cellulose, chitin, and keratin, which are difficult to degrade. Thus, because of the microscopic fungal activity, the substances return to the ecosystem cycle of matter in the form accessible to plants [1, 2], which is especially(More)
3D cell cultures are extensively used to study in vitro toxic effect of xenobiotics. When using multicellular spheroids, the question about their optimal size should be solved: small spheroids are difficult to manipulate, while large size of spheroids impairs the transport of nutrients and oxygen into the center. Mathematical models describing the(More)
The surface and internal tissues of the fruiting bodies of basidiomycetes were shown to be specific bacterial habitats characterized by varying diversity and structure of bacterial complexes. On the surface of fruiting bodies, Gram-negative bacteria of the genera Pseudomonas, Xanthomonas, and Myxococcus prevailed, while in the internal tissues Gram-positive(More)