Alicia Plumer

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Osteopontin (OPN) is associated with human cancers, and circulating blood OPN may have diagnostic or prognostic value in clinical oncology. To evaluate OPN as a cancer biomarker, we generated and characterized five novel mouse monoclonal antibodies against the human full-length OPN (fl-OPN). Epitopes recognized by four antibodies (2C5, 2F10, 2H9, and 2E11)(More)
The molecular genetic mechanisms of colorectal cancer are among the best understood of any common cancer. Recent research has identified mutated tumor suppressor genes and oncogenes as normal tissue progresses from benign to malignant, and the novel mismatch repair genes involved in a specific form of hereditary colorectal cancer as well as a significant(More)
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