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Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
Prostaglandin (PG) E2 is formed from PGH2 by a series of PGE synthase (PGES) enzymes. Microsomal PGES-1−/− (mPGES-1−/−) mice were crossed into low-density lipoprotein receptor knockout (LDLR−/−) miceExpand
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Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis.
Fibroblast activation protein (FAPalpha) is a member of the cell surface dipeptidyl peptidase (DPP) family of serine proteases. In its dimer form, FAPalpha exhibits gelatinase, collagenase, and DPPExpand
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Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease
Though Abl inhibitors are often successful therapies for the initial stages of chronic myelogenous leukemia (CML), refractory cases highlight the need for novel molecular insights. We demonstrateExpand
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Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease
Middleton et al. 2006. J. Exp. Med. doi:10.1084/jem.20061444 [OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
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Cyclooxygenases, Thromboxane, and Atherosclerosis: Plaque Destabilization by Cyclooxygenase-2 Inhibition Combined With Thromboxane Receptor Antagonism
Background—Antagonism or deletion of the receptor (the TP) for the cyclooxygenase (COX) product thromboxane (Tx)A2, retards atherogenesis in apolipoprotein E knockout (ApoE KO) mice. AlthoughExpand
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CD44 Expressed on Both Bone Marrow–Derived and Non–Bone Marrow–Derived Cells Promotes Atherogenesis in ApoE-Deficient Mice
  • L. Zhao, E. Lee, +6 authors E. Puré
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 July 2008
Objective—The purpose of this study was to distinguish the contributions of CD44 expressed on bone marrow–derived and non–bone marrow–derived cells to atherosclerosis. Methods and Results—Using boneExpand
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Autologous Stem‐Cell Transplantation for Primary Central Nervous System Lymphoma: Systematic Review and Meta‐analysis
Background: Primary central nervous system lymphoma (PCNSL) is an aggressive form of non‐Hodgkin lymphoma. Methotrexate is first‐line chemotherapy. Autologous stem‐cell transplantation (ASCT) isExpand
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CD44 Regulates Vascular Gene Expression in a Proatherogenic Environment
  • L. Zhao, J. Hall, +6 authors E. Puré
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 April 2007
Objective—To identify early changes in vascular gene expression mediated by CD44 that promote atherosclerotic disease in apolipoprotein E (apoE)–deficient (apoE−/−) mice. Methods and Results—WeExpand
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12/15-Lipoxygenase-Dependent Myeloid Production of Interleukin-12 Is Essential for Resistance to Chronic Toxoplasmosis
ABSTRACT Interleukin-12 (IL-12) is critical for resistance to Toxoplasma gondii during both the acute and chronic stages of infection. However, the cellular and molecular pathways that regulate IL-12Expand
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Geographically Remote Cerebral Venous Sinus Thrombosis in Patients with Intracranial Tumors.
Cerebral venous sinus thrombosis (CVST) related to intracranial tumors has most commonly been recognized as an operative complication related to local operative factors such as retraction or directExpand
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