Alicia Coughlin

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We examined the development of striped and spotted pigmentation by comparing and contrasting wildtype zebrafish (striped) with fish carrying the leopard mutation (spotted). We hypothesized that WT and leopard mutant fish would differ in pigmentation during larval and juvenile stages. Surprisingly, we found that the pigment formed similar complex but ordered(More)
Zebrafish with defective Nodal signaling have a phenotype analogous to the fatal human birth defect anencephaly, which is caused by an open anterior neural tube. Previous work in our laboratory found that anterior open neural tube phenotypes in Nodal signaling mutants were caused by lack of mesendodermal/mesodermal tissues. Defects in these mutants are(More)
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