Alicia C Reid

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Ventricular volumes have been measured from CT scans of patients with benign intracranial hypertension both at initial presentation and at a later date. Volumes initially were smaller than normal, but at review five patients showed a significant increase in ventricular size. Persisting small ventricular volume correlated with persisting symptoms and signs(More)
MS-275 (Entinostat) is a histone deacetylase (HDAC) inhibitor currently in clinical trials for the treatment of several types of cancer. Recent reports have noted that MS-275 can cross the blood brain barrier (BBB) and cause region specific changes in rodent brain histone acetylation. To characterize the pharmacokinetics and distribution of MS-275 in the(More)
Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition to low HDAC potency and selectivity observed, poor brain penetrance may account for the high doses needed to achieve therapeutic efficacy. Here we report the development(More)
The volume of the lateral and third ventricles was measured by a non-invasive computerised axial tomographic method in 18 patients presenting with characteristic features of benign intracranial hypertension. Values obtained were significantly lower than in 18 controls matched for age and sex. The demonstration of smaller-than-normal ventricles in benign(More)
Levels of arginine vasopressin have been measured in the blood and cerebrospinal fluid of patients with benign intracranial hypertension and raised intracranial pressure, patients with other neurological diseases and in normal control subjects. There was no difference in blood levels in each of the 3 groups (mean +/- SEM, 2.8 +/- 0.5, 2.5 +/- 0.25, 2.53 +/-(More)
We examined the effects of dexamethasone administration and withdrawal on regional cerebral blood flow (CBF) and the permeability surface area (PS) product for water in the central nervous system of conscious rats. There were no significant changes in CBF. Dexamethasone treatment produced a significant decrease in the PS product for water in the cerebral(More)
We had reported that activation of presynaptic histamine H(3)-receptors inhibits norepinephrine exocytosis from depolarized cardiac sympathetic nerve endings, an action associated with a marked decrease in intraneuronal Ca(2+) that we ascribed to a decreased Ca(2+) influx. An H(3)-receptor-mediated inhibition of cAMP-dependent phosphorylation of Ca(2+)(More)
We have shown that steroid manipulations may influence the rate of flux of water across the blood-brain barrier. Such changes are regionally variable and are best seen in the cerebral cortex. Administration of dexamethasone produced decreased water permeability while withdrawal of dexamethasone and ethinyloestradiol resulted in increased permeability.(More)
A new model for homogeneous nucleation of structural phase transformations, which can span the range of nucleation from classical to nonclassical, is presented. This model is extended from the classical nucleation theory by introducing driving-force dependencies into the interfacial free energy, the misfit strain energy, and the nucleus chemical free-energy(More)