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Repeated stress is an important risk factor for the development of depression. However, the mechanism by which stress influences depression is largely unknown, in part due to the fact that few animal models of repeated stress produce robust changes in depression-like behavior. The purpose of the present study was to characterize the effect of repeated(More)
Modeling fear in animals is a critical approach for identifying the neural mechanisms involved in human disorders such as generalized anxiety and panic. Amygdala kindling has proven useful in this regard because it produces dramatic increases in fearful behavior. The purpose of this experiment was to compare the behavioral effects of kindling in male and(More)
Kindling dramatically increases fearful behavior in rats. Because kindling-induced fear increases in magnitude as rats receive more stimulations, kindling provides a superb opportunity to study the nature and neural mechanisms of fear sensitization. Interestingly, these changes in behavior are accompanied by increased binding to inhibitory receptors and(More)
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