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Epithelia play important immunological roles at a variety of mucosal sites. We examined NFkappaB activity in control and TNF-alpha treated bovine mammary epithelial monolayers (BME-UV cells). A(More)
OBJECTIVE To examine the regulation and mode of action of peripheral corticotropin-releasing hormone (CRH) in human inflammatory arthritis. METHODS CRH messenger RNA (mRNA) levels were measured in(More)
Modulation of the NURR subfamily of nuclear receptors may be an important mechanism regulating pathways associated with inflammatory joint disease. We examined the signaling mechanisms through which(More)
OBJECTIVE Elevated levels of corticotropin-releasing hormone (CRH) are produced locally in inflamed human synovial tissue, and previous observations indicate a role for CRH in the pathogenesis of(More)
Modulation by proinflammatory mediators indicate that NURR1 induction represents a point of convergence of distinct signaling pathways, suggesting an important common role for this transcription(More)
OBJECTIVE To determine a mechanism by which corticotropin-releasing hormone (CRH) promotes human inflammatory joint disease progression. METHODS An ex vivo synovial tissue culture system was(More)