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Routine OGTT: A Robust Model Including Incretin Effect for Precise Identification of Insulin Sensitivity and Secretion in a Single Individual

• Andrea De Gaetano, Simona Panunzi, +4 authors Giovanni Pacini
• PloS one
• 2013

In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT) observations, a relatively simple mathematical model (Simple Interdependent glucose/insulin MOdel SIMO) for the OGTT, which coherently incorporates commonly accepted physiological assumptions (incretin effect and saturating… (More)

Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.

• Alice Matone, Marie-Pier Scott-Boyer, +9 authors Jörg Hager
• PloS one
• 2016

BACKGROUND AND SCOPE Weight loss success is dependent on the ability to refrain from regaining the lost weight in time. This feature was shown to be largely variable among individuals, and these differences, with their underlying molecular processes, are diverse and not completely elucidated. Altered plasma metabolites concentration could partly explain… (More)

Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects

• Alice Matone, Eleonora Derlindati, +7 authors Riccardo C Bonadonna
• PloS one
• 2017

Insulin resistance is considered to be a pathogenetic mechanism in several and diverse diseases (e.g. type 2 diabetes, atherosclerosis) often antedating them in apparently healthy subjects. The aim of this study is to investigate with a microarray based approach whether IR per se is characterized by a specific pattern of gene expression. For this purpose we… (More)

Body mass index mediates inflammatory response to acute dietary challenges.

• Alice Matone, Colm M O'Grada, +8 authors Helen M Roche
• Molecular nutrition & food research
• 2015

SCOPE Acute metabolic challenges provide an opportunity to identify mechanisms of metabolic and nutritional health. In this study, we assessed the transcriptomic response to oral glucose and lipid challenges in a cohort of individuals ranging in age and BMI. The main goal is to identify whether BMI can mediate the metabolic and transcriptional response to… (More)

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