Alice Matone

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Bariatric surgery and T2DM improvement mechanisms: a mathematical model

Puntip Toghaw, Alice Matone, Yongwimon Lenbury, Andrea de Gaetano
Theoretical Biology and Medical Modelling
2012

Consensus exists that several bariatric surgery procedures produce a rapid improvement of glucose homeostasis in obese diabetic patients, improvement apparently uncorrelated with the degree of… (More)

Routine OGTT: A Robust Model Including Incretin Effect for Precise Identification of Insulin Sensitivity and Secretion in a Single Individual

Andrea de Gaetano, Simona Panunzi, +4 authors Giovanni Pacini
PloS one
2013

In order to provide a method for precise identification of insulin sensitivity from clinical Oral Glucose Tolerance Test (OGTT) observations, a relatively simple mathematical model (Simple… (More)

Statistical Evaluation of a Glucose / Insulin Nonlinear Differential Equation Model with Classical and Bayesian Procedures

SUTHAROT LUEABUNCHONG, Yongwimon Lenbury, Simona Panunzi, Alice Matone
2012

In this paper, the Markov Chain Monte Carlo (MCMC) method and Generalized Least Square (GLS) method are used to estimate the parameters in a glucose/insulin nonlinear differential model with GLP1DPP4… (More)

Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73)

Mario Lauria, Maria Persico, +9 authors François-Pierre J. Martin
Scientific Reports
2017

In longitudinal clinical studies, methodologies available for the analysis of multivariate data with multivariate methods are relatively limited. Here, we present Consensus Clustering (CClust) a new… (More)

Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects

Alice Matone, Eleonora Derlindati, +7 authors Riccardo C Bonadonna
PloS one
2017

Insulin resistance is considered to be a pathogenetic mechanism in several and diverse diseases (e.g. type 2 diabetes, atherosclerosis) often antedating them in apparently healthy subjects. The aim… (More)

Modeling rejection immunity

Andrea De Gaetano, Alice Matone, Annamaria Agnes, Pasquale Palumbo, Francesco Ria, Sabina Magalini
Theoretical Biology and Medical Modelling
2012

Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft), immunosuppression therapies are used, which… (More)

Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.

Alice Matone, Marie-Pier Scott-Boyer, +9 authors Jörg Hager
PloS one
2016

BACKGROUND AND SCOPE Weight loss success is dependent on the ability to refrain from regaining the lost weight in time. This feature was shown to be largely variable among individuals, and these… (More)

A closed-loop multi-level model of glucose homeostasis

Cansu Uluseker, Giulia Simoni, Luca Marchetti, Marco Dauriz, Alice Matone, Corrado Priami
PloS one
2018

BACKGROUND The pathophysiologic processes underlying the regulation of glucose homeostasis are considerably complex at both cellular and systemic level. A comprehensive and structured specification… (More)

A computationally driven analysis of the polyphenol-protein interactome

Sébastien Lacroix, Jasna Klicic Badoux, +6 authors Sofia Moço
Scientific Reports
2018

Polyphenol-rich foods are part of many nutritional interventions aimed at improving health and preventing cardiometabolic diseases (CMDs). Polyphenols have oxidative, inflammatory, and/or metabolic… (More)

Body mass index mediates inflammatory response to acute dietary challenges.

Alice Matone, Colm M O'Grada, +8 authors Helen M. Roche
Molecular nutrition & food research
2015

SCOPE Acute metabolic challenges provide an opportunity to identify mechanisms of metabolic and nutritional health. In this study, we assessed the transcriptomic response to oral glucose and lipid… (More)

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