Alice Macdonald

Learn More
BACKGROUND There have been many assumptions made about neuronal loss in mammals due to aging. However, when we examined the retinal ganglion cell layer of a marsupial, the quokka, from 0.5 to 13.5 years of age, we found that the total neuron number did not decrease significantly even into extreme old age. The retinal area increased slowly throughout life,(More)
Cell-cell signaling is an important component of the stem cell microenvironment, affecting both differentiation and self-renewal. However, traditional cell-culture techniques do not provide precise control over cell-cell interactions, while existing cell-patterning technologies are limited when used with proliferating or motile cells. To address these(More)
In migrating cells, with especial prominence in lamellipodial protrusions at the cell front, highly dynamic connections are formed between the actin cytoskeleton and the extracellular matrix through linkages of integrin adhesion receptors to actin filaments via complexes of cytosolic "connector" proteins. Myosin-mediated contractile forces strongly(More)
We have defined the defect in the tapetum of beagles with an inherited tapetal abnormality to be the absence of both zinc and cysteine from the tapetal rods. This was demonstrated by direct measurement of zinc and cysteine and by histochemical localization of zinc. The latter method also indicated an interesting substructure in tapetal rods from normal(More)
Methods for the analysis of polyether antibiotics in animal tissues and fluids are described. For monensin and nigericin, only methods based on bioautography are available. For lasalocid, in addition to TLC bioautography for quantitation in chicken skin and fat, LC methods based on fluorescence detection have been developed for quantitation in animal blood,(More)
This study was undertaken to determine whether present regulations for discarding milk from cows treated with sulfadimethoxine (SDM) can be supported by modern analytical methodology. Two groups of milking cows (10 in first group; 11 in the second) were treated orally with SDM at the recommended dose levels for 5 days. The SDM concentration in the milk was(More)
  • 1