Alice D C Hoftman

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OBJECTIVE The genetic association of interferon regulatory factor 5 (IRF5) with systemic lupus erythematosus (SLE) susceptibility has been convincingly established. To gain understanding of the effect of IRF5 variation in individuals without SLE, a study was undertaken to examine whether such genetic variation predisposes to activation of the interferon(More)
INTRODUCTION Osteopontin (OPN) has been implicated as a mediator of Th17 regulation via type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair. This study assessed whether increased circulating plasma OPN (cOPN) precedes development of organ damage in pediatric systemic lupus erythematosus (pSLE) and compared it to(More)
OBJECTIVE Melanoma-associated antigen gene B2 (MAGE-B2) encodes an embryonic antigen normally silenced after birth except in testis and placenta. We identified the MAGE-B2 gene and autoantibodies in pediatric patients with systemic lupus erythematosus (SLE) glomerulonephritis. We investigated the prevalence of MAGE-B2 autoantibodies in association with(More)
Purpose Osteopontin (OPN) is a secreted phosphoprotein functioning in monocyte and T cell adhesion and migration. Expression of OPN in alternatively-activated macrophages has been implicated in post-inflammatory fibrosis of lung and kidney. In our previously conducted cross-sectional study of 72 pediatric SLE patients (pSLE; age of onset <18 years),(More)
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