Alice B. Brandwein

Learn More
Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship between(More)
Successful integration of auditory and visual inputs is crucial for both basic perceptual functions and for higher-order processes related to social cognition. Autism spectrum disorders (ASD) are characterized by impairments in social cognition and are associated with abnormalities in sensory and perceptual processes. Several groups have reported that(More)
Successful integration of signals from the various sensory systems is crucial for normal sensory-perceptual functioning, allowing for the perception of coherent objects rather than a disconnected cluster of fragmented features. Several prominent theories of autism suggest that automatic integration is impaired in this population, but there have been few(More)
The integration of multisensory information is essential to forming meaningful representations of the environment. Adults benefit from related multisensory stimuli but the extent to which the ability to optimally integrate multisensory inputs for functional purposes is present in children has not been extensively examined. Using a cross-sectional approach,(More)
The visual system can automatically interpolate or "fill-in" the boundaries of objects when inputs are fragmented or incomplete. A canonical class of visual stimuli known as illusory-contour (IC) stimuli has been extensively used to study this contour interpolation process. Visual evoked potential (VEP) studies have identified a neural signature of these(More)
The adult human visual system can efficiently fill-in missing object boundaries when low-level information from the retina is incomplete, but little is known about how these processes develop across childhood. A decade of visual-evoked potential (VEP) studies has produced a theoretical model identifying distinct phases of contour completion in adults. The(More)
BACKGROUND Niemann-Pick type C (NPC) is an autosomal recessive disease in which cholesterol and glycosphingolipids accumulate in lysosomes due to aberrant cell-transport mechanisms. It is characterized by progressive and ultimately terminal neurological disease, but both pre-clinical studies and direct human trials are underway to test the safety and(More)
  • 1