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BACKGROUND Head and neck cancer including oral cancer is considered to develop by accumulated genetic alterations and the major pathway is cancerization from lesions such as intraepithelial dysplasia in oral leukoplakia and erythroplakia. The relationship of proliferation markers with the grading of dysplasia is uncertain. The involvement of EBV in oral(More)
BACKGROUND Matrix metalloproteinases (MMPs) play an important role in the modeling and remodeling of the extracellular matrix in both physiologic and pathologic states and thus plays an important role in tumor progression. Human collagenase-3 (MMP-13) is a member of matrix metalloproteinase family of enzymes that was originally identified in breast(More)
In this article, we present a new method for the generation of surface meshes of biological soft tissue. The method is based on the deformable surface model technique and is extended to histological data sets. It relies on an iterative adjustment towards polygonal segments describing the histological structures of the soft tissue. The generated surface(More)
We achieved possibility of isolation, characterization human umbilical cord blood endothelial progenitor cells (EPCs), examination potency of EPCs to form new blood vessels and differentiation into cardiomyoctes in canines with acute myocardial infarction (AMI). EPCs were separated and cultured from umbilical cord blood. Their phenotypes were confirmed by(More)
Kurzfassung. In dieser Arbeit wird ein Verfahren zur Rekonstruktion eines dreidimensionalen Oberflächenmodells aus Serienschnitten vorgestellt, die sich von Lippen-Kiefer-Gaumenspalten (kurz LKG) ableiten und insbesondere die in der chirurgischen Behandlung relevanten medizinischen Strukturen berücksichtigen. Die Intention ist, ein aktives Polygonnetz(More)
Integrated information on ultrastructural surface texture and chemistry increasingly plays a role in the biomedical sciences. Light microscopy provides access to biochemical data by the application of dyes. Ultrastructural representation of the surface structure of tissues, cells, or macromolecules can be obtained by scanning electron microscopy (SEM).(More)
Es gibt mannigfaltige Wege, virtuelles Gewebe herzustellen. Erste Schritte dorthin können über die Herstellung virtueller Zellen führen. Eine „Quaoaring“ genannte Methode wurde genutzt, um artifizielle Erythrozyten sowohl der Diskozyten- als auch der Echinozytenform zu erzeugen. Die Ergebnisse wurden mit Daten aus der Rasterelektronenmikroskopie und der(More)
Diese Arbeit beschreibt einen neuen Algorithmus zur (semi)automatischen Segmentierung histologischer und zytologischer Präparate. Bedingt durch den Umstand, dass derartige Präparate teilweise nur wenige kontrastreiche Areale und kaum scharfe Konturen aufweisen, sind klassische Segmentierungsverfahren wenig Erfolg versprechend, die relevanten Strukturen zu(More)
Competing concepts exist regarding surgery for instance of the cleft lip and palate to date. Morphology-based simulations at histological scale may one day be used to help the surgeon predict the possible outcome of a variety of approaches. It however can be a challenge to generate volume meshes that are applicable to the mathematical modelling of(More)
INTRODUCTION Melanocytes in skin are derived from the neural crest and colonize the epidermis in the first trimester of gestation. Melanocytes have been observed in the nasopharyngeal, inner ear and oral mucosa and should therefore be present in the middle ear mucosa. AIMS To identify and determine the distribution of melanocytes in human cholesteatoma(More)
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