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  • Haideh Motamedi, Ali Shafiee, S J Cai, Stanley L. Streicher, Byron H. Arison, Randy R. Miller
  • Biology, Medicine
  • Journal of bacteriology
  • 1996 (First Published: 1 September 1996)
  • FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive and antifungal activities. The gene encoding 31-O-demethyl-FK506 methyltransferase, fkbM, was isolated fromContinue Reading
  • Ali Shafiee, C. Richard Hutchinson
  • Chemistry, Medicine
  • Biochemistry
  • 1987 (First Published: 22 September 1987)
  • A cytochrome P-450 monooxygenase that catalyzes the hydroxylation of 6-deoxyerythronolide B, an intermediate of erythromycin A biosynthesis in Saccharopolyspora erythraea (formerly StreptomycesContinue Reading
  • Sheo Baran Singh, Hiranthi Jayasuriya, +10 authors Dj Hazuda
  • Chemistry, Medicine
  • Journal of natural products
  • 2001 (First Published: 1 July 2001)
  • From the screening of a microbial extract library, isocomplestatin (1), a new axial-chiral isomer of complestatin (2) which is a known rigid bicyclic hexapeptide, was identified as a potent naturalContinue Reading
  • Ali Shafiee, C. Richard Hutchinson
  • Biology, Medicine
  • Journal of bacteriology
  • 1988 (First Published: 1 April 1988)
  • The hydroxylation of 6-deoxyerythronolide B (6D) to erythronolide B, a step in the biosynthesis of the 14-membered macrolide antibiotic erythromycin A by Saccharopolyspora erythraea, is catalyzed byContinue Reading