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It is generally thought that the DNA-damage checkpoint kinases, ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR), work independently of one another. Here, we show that ATM and the… (More)
DNA double-strand breaks (DSBs) can be processed by the Mre11-Rad50-Nbs1 (MRN) complex, which is essential to promote ataxia telangiectasia-mutated (ATM) activation. However, the molecular mechanisms… (More)
Objectives: This study examined the effectiveness of psychosocial rehabilitation in reducing negative symptoms and improving social skills in chronic schizophrenia patients. Method: In this… (More)
The purpose of this study is to adapt, normalize and to determine reliability and validity of W1SC-. At adaptation stage, 835 students were selected through a systematic random sampling from 30… (More)
Epidermolysis bullosa (EB) is a heterogeneous group of heritable blistering diseases. We developed a next generation sequencing (NGS) panel covering 21 genes associated with skin fragility disorders,… (More)
Homozygosity mapping (HM), also known as autozygosity mapping, was originally used to map genes underlying homozygous autosomal recessive Mendelian diseases in patients from closely genetically… (More)