Ali Nadim

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The dynamic cerebral blood flow response to sudden hypotension during posture change is poorly understood. To better understand the cardiovascular response to hypotension, we used a windkessel model with two resistors and a capacitor to reproduce beat-to-beat changes in middle cerebral artery blood flow velocity (transcranial Doppler measurements) in(More)
The transcription factor p53 is an important regulator of cell fate. Mutations in p53 gene are associated with many cancers. In response to signals such as DNA damage , p53 controls the transcription of a series of genes that cause cell cycle arrest during which DNA damage is repaired, or triggers programmed cell death that eliminates possibly cancerous(More)
Several recent experiments on DNA-damage-induced signaling networks in mammalian cells have shown interesting dynamics in p53 protein expression during the repair cycle. Pulses of p53 are produced, whose frequency and amplitude are fairly independent of the amount of damage, but the probability of a cell exhibiting this pulsatile behavior increases with(More)
Whether tracking the eye of a storm, the leading edge of a wildfire, or the front of a chemical reaction, one finds that significant change occurs at the thin edge of an advancing line. The tracking of such change-fronts comes in myriad forms with a wide variety of applications. Our research over the past two years combines fast multiresolution methods with(More)
In all living organisms, oxygen transport from arterioles to the surrounding tissue is critical for survival. However, the exact nature of the transport of oxygen from the arteriole to the surrounding tissue remains shrouded in mystery, in part because the experimental data are not in accordance with the well-established Krogh diffusion model. In this(More)
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