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The radiofrequency (RF) transmit field is severely inhomogeneous at ultrahigh field due to both RF penetration and RF coil design issues. This particularly impairs image quality for sequences that use inversion pulses such as magnetization prepared rapid acquisition gradient echo and limits the use of quantitative arterial spin labeling sequences such as(More)
OBJECTIVE Histologic examination of multiple sclerosis (MS) brain lesions reveals heterogeneity including the presence or absence of a central blood vessel. Recent work has shown that T2* weighted magnetic resonance imaging at 7T allows the identification of small parenchymal veins within MS lesions. The aims of this study were (1) to compare whether a(More)
Cortical lesions are prevalent in multiple sclerosis but are poorly detected using MRI. The double inversion recovery (DIR) sequence is increasingly used to explore the clinical relevance of cortical demyelination. Here we evaluate the agreement between imaging sequences at 3 Tesla (T) and 7T for the presence and appearance of individual multiple sclerosis(More)
Diverse pathological changes occur in the white matter (WM) of patients with schizophrenia. Various microstructural alterations including a reduction in axonal number or diameter, reduced myelination, or poor coherence of fibers could account for these changes. Abnormal integrity of macromolecules such as myelin ('dysmyelination') can be studied by applying(More)
OBJECTIVE The aim of this study was to compare the use of high-resolution phase and QSM images acquired at ultra-high field in the investigation of multiple sclerosis (MS) lesions with peripheral rings, and to discuss their usefulness for drawing inferences about underlying tissue composition. MATERIALS AND METHODS Thirty-nine Subjects were scanned at 7(More)
This study used quantitative MRI to study normal appearing white matter (NAWM) in patients with clinically isolated syndromes suggestive of multiple sclerosis and relapsing-remitting multiple sclerosis (RRMS). This was done at ultrahigh field (7 T) for greater spatial resolution and sensitivity. 17 CIS patients, 11 RRMS patients, and 20 age-matched healthy(More)
The radiofrequency (RF) transmit field is severely inhomoge-neous at ultrahigh field due to both RF penetration and RF coil design issues. This particularly impairs image quality for sequences that use inversion pulses such as magnetization prepared rapid acquisition gradient echo and limits the use of quantitative arterial spin labeling sequences such as(More)
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