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Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment
We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).
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Functional characterization of a novel TREM2 coding variant linked to familial Alzheimer’s disease
APOE status with each individual miRNA. Notably, interactions of miR1013miR346 and miR1533miR346 were also significant. Cook’s D test identified one outlier (D 1⁄4 7.31). However, the sameExpand
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PROSPECTIVE ASSOCIATIONS BETWEEN VITAMINS, METABOLITES, AND OVERALL DEMENTIA IN THE OLDEST-OLD
Related factors of cognitive decline in community-dwelling elderly people are gender (male), alcohol consumption, smoking and employment (past). Thus, it is important that related factors open toExpand
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Genome-wide association study using cerebrospinal fluid biomarkers beta-amyloid-42 and pTau181 in German samples of Alzheimer's disease
CEREBROSPINAL FLUID BIOMARKERS BETAAMYLOID-42 AND PTAU181 IN GERMAN SAMPLES OFALZHEIMER’S DISEASE Alfredo Ramirez, Christine Herold, Piotr Lewczuk, Andr e Lacour, Dmitriy Drichel, Britta Sch€urmann,Expand
THE APOE-ε4 ALLELE AND AGE SYNERGISTICALLY DRIVE DISEASE PROGRESSION IN ALZHEIMER’S DISEASE
Abstract The Apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD) and other neurodegenerative dementias. Cross-sectional case-control studies suggestExpand
COMPREHENSIVE GENE-GENE INTERACTION META-ANALYSIS OF IGAP GWA STUDIES
original subject level dataset were performed and mixed-model repeated measures (MMRM) analyses of post-baseline changes up to 18 (semagacestat/solanezumab) or 24 (ADNI) months were run on eachExpand
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APOE-ε4 MODULATES LEVELS OF OMEGA-3 AND OMEGA-6 FATTY ACIDS IN ALZHEIMER’S DISEASE DEMENTIA
a clinical diagnosis of Alzheimer’s’ disease (AD). Here, we report on the data we obtained in a larger cohort of patients with clinically diagnosed AD or Frontotemporal Dementia (FTD). Methods: TheExpand