Alfredo Guarino

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OBJECTIVES Rotavirus is the leading cause of acute gastroenteritis requiring hospitalization in young children. Data on the burden of rotavirus gastroenteritis are needed to guide recommendations for rotavirus vaccine use. This study was undertaken to estimate the burden of rotavirus gastroenteritis in European children <5 years of age. METHODS This(More)
AIMS To assess the incidence of intestinal inflammation in children with cystic fibrosis and to investigate whether probiotics decrease it. STUDY DESIGN In this two-phase, controlled, prospective study, faecal calprotectin was measured by enzyme-linked immunosorbent assay in 30 children with cystic fibrosis, 30 healthy controls and 15 children with active(More)
Members A. ACCORSI, E. ADRARIO, F. AGRÒ, G. AMICUCCI, M. ANTONELLI, F. AZZERI, S. BARONCINI, G. BETTELLI, C. CAFAGGI, D. CATTANO, E. CHINELLI, U. CORBANESE, R. CORSO, A. DELLA PUPPA, A. DI FILIPPO, E. FACCO, R. FAVARO, R. FAVERO, G. FROVA, F. GIUNTA, G. GIURATI, F. GIUSTI, A. GUARINO, E. IANNUZZI, G. IVANI, D. MAZZON, M. MENARINI, G. MERLI, E. MONDELLO, S.(More)
BACKGROUND & AIM The addition of prebiotics to infant formula modifies the composition of intestinal microflora. Aim of the study was to test the hypothesis that prebiotics reduce the incidence of intestinal and respiratory infections in healthy infants. METHODS A prospective, randomized, placebo-controlled, open trial was performed. Healthy infants were(More)
OBJECTIVES These guidelines update and extend evidence-based indications for the management of children with acute gastroenteritis in Europe. METHODS The guideline development group formulated questions, identified data, and formulated recommendations. The latter were graded with the Muir Gray system and, in parallel, with the Grading of Recommendations,(More)
Following the experience of cardiac surgeons with homografts in the treatment of infective aortic valve endocarditis, cardiovascular surgeons have investigated in situ revascularization by means of homografts in the management of vascular prosthetic graft infections. Preliminary results are encouraging, but their late fate in long-term follow-up and the(More)
BACKGROUND & AIMS Intestinal inflammation is a hallmark of cystic fibrosis (CF). Administration of probiotics can reduce intestinal inflammation and the incidence of pulmonary exacerbations. We investigated the composition of intestinal microbiota in children with CF and analyzed its relationship with intestinal inflammation. We also investigated the(More)
BACKGROUND & AIMS Probiotics reduce intestinal inflammation in children with cystic fibrosis (CF). We want to determine the effects of Lactobacillus GG (LGG) on pulmonary exacerbations in CF. METHODS A prospective, randomized, placebo-controlled, cross-over study was performed. Nineteen children received LGG for 6 months and then shifted to oral(More)
We report on two sisters affected by congenital alopecia, nail dystrophy, and a severe T-cell immunodeficiency, presumably inherited as an autosomal-recessive disorder. The T-cell defect was characterized by severe functional impairment, as shown by the lack of proliferative response and upregulation of activation markers following mitogen stimulation. The(More)