Alfredo Carlos Simões Dornellas de Barros

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BACKGROUND Although various techniques have been used for breast conservation surgery reconstruction, there are few studies describing a logical approach to reconstruction of these defects. The objectives of this study were to establish a classification system for partial breast defects and to develop a reconstructive algorithm. METHODS The authors(More)
Intratumoral heterogeneity (ITH) represents an obstacle for cancer diagnosis and treatment, but little is known about its functional role in cancer progression. The A Desintegrin And Metalloproteinase 23 (ADAM23) gene is epigenetically silenced in different types of tumors, and silencing is often associated with advanced disease and metastasis. Here, we(More)
The objective of this study is to describe the surgical planning of the inferior dermoglandular pedicle (IDP) technique and its outcome following partial mastectomy reconstruction. A total of 26 patients with breast cancer underwent immediate IDP reconstruction. IDP was indicated to reconstruct superior/central breast defects. Postoperative complications(More)
PURPOSE To present local control, complications, and cosmetic outcomes of intraoperative radiation therapy (IORT) for early breast cancer, as well as technical aspects related to the use of a nondedicated linear accelerator. METHODS AND MATERIALS This prospective trial began in May of 2004. Eligibility criteria were biopsy-proven breast-infiltrating(More)
OBJECTIVES AND BACKGROUND The objective of the present study was to determine whether neoadjuvant chemotherapy in women with breast cancer larger than 3 cm associated with breast-conserving surgery plus intraoperative evaluation of surgical margins is safe. METHODS A total of 164 patients with breast cancer larger than 3 cm in diameter were submitted to(More)
PURPOSE/OBJECTIVE(S) Skin sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) have entered routine surgical practice for breast cancer, though their oncologic safety has not been established in randomized controlled trials. The aim of this study was to evaluate and compare radiation oncologists' and breast surgeons' opinions concerning the(More)
e11560 Background: To report single-institution series of breast intra-operative radiotherapy (IORT) using nondedicated linear accelerator. METHODS Prospective phaseII trial opened in May 2004. Eligibility criteria: single-focal breast infiltrating ductal carcinoma, age >40 years, size <3cm (after February 2009 >50 years and <2cm) and cN0. EXCLUSION(More)
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