Alfred Leitenstorfer

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Magnetic resonance imaging and optical microscopy are key technologies in the life sciences. For microbiological studies, especially of the inner workings of single cells, optical microscopy is normally used because it easily achieves resolution close to the optical wavelength. But in conventional microscopy, diffraction limits the resolution to about half(More)
Poly(ADP-ribose) (PAR) is a complex and reversible post-translational modification that controls protein function and localization through covalent modification of, or noncovalent binding to target proteins. Previously, we and others characterized the noncovalent, high-affinity binding of the key nucleotide excision repair (NER) protein XPA to PAR. In the(More)
We directly trace the multi-THz conductivity of VO2 during an insulator-metal transition triggered by a 12-fs light pulse. The femtosecond dynamics of lattice and electronic degrees of freedom are spectrally discriminated. A coherent wave packet motion of V-V dimers at 6 THz modulates the lattice polarizability for approximately 1 ps. In contrast, the(More)
Ultrafast charge and spin excitations in the elusive terahertz regime1,2 of the electromagnetic spectrum playa pivotal role in condensed matter3-13• The electric field of free-space terahertz pulses has provided a direct gateway to manipulating the motion of charges on the femtosecond timescale6-9 • Here, we complement this process by showing that the(More)
Highly confined DNA damage by femtosecond laser irradiation currently arises as a powerful tool to understand DNA repair in live cells as a function of space and time. However, the specificity with respect to damage type is limited. Here, we present an irradiation procedure based on a widely tunable Er/Yb : fiber femtosecond laser source that favors the(More)
We have fabricated all-dielectric high-Q optical pillar resonators with embedded colloidal CdSe/ZnS quantum dots or rods as light emitters by focused ion beam milling. Three-dimensional light confinement and distinct pillar microcavity modes are observed. Results from a waveguide model for the mode patterns and their spectral positions are in excellent(More)
Xeroderma pigmentosum group C (XPC) protein initiates the DNA excision repair of helix-distorting base lesions. To understand how this versatile subunit searches for aberrant sites within the vast background of normal genomic DNA, the real-time redistribution of fluorescent fusion constructs was monitored after high-resolution DNA damage induction.(More)
Electrostatic coupling between particles is important in many microscopic phenomena found in nature. The interaction between two isolated point charges is described by the bare Coulomb potential, but in many-body systems this interaction is modified as a result of the collective response of the screening cloud surrounding each charge carrier. One such(More)
Phase-locked terahertz transients with peak electric fields of 108 MV/cm and center frequencies continuously tunable from 10 to 72 THz are generated via difference-frequency mixing of two parametrically amplified pulse trains from a single white-light seed. Free space electro-optic sampling with 8 fs gating pulses from a two-branch Er:fiber laser allows us(More)
Mode-locked erbium-doped fiber lasers are ideal comb generators for optical frequency metrology. We compare two fiber frequency combs by measuring an optical frequency independently with both combs and comparing their results. The two frequency measurements agree within 6x10-16. This is to our knowledge the first direct comparison between two fiber based(More)