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  • Kenneth L Rock, Colette F. Gramm, L Rothstein, Karen Clark, Alfred L Goldberg
  • Medicine, Biology
  • Cell
  • 1994 (First Publication: 1 September 1994)
  • Reagents that inhibit the ubiquitin-proteasome proteolytic pathway in cells have not been available. Peptide aldehydes that inhibit major peptidase activities of the 20S and 26S proteasomes are shownExpand
  • Jinghui Zhao, Jeffrey J Brault, +5 authors Alfred L Goldberg
  • Medicine, Biology
  • Cell metabolism
  • 2007 (First Publication: 5 December 2007)
  • Muscle atrophy occurs in many pathological states and results primarily from accelerated protein degradation and activation of the ubiquitin-proteasome pathway. However, the importance of lysosomesExpand
  • Marcelo Damário Gomes, Stewart H. Lecker, R Thomas Jagoe, Ami Navon, Alfred L Goldberg
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2001 (First Publication: 20 November 2001)
  • Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein degradation by the ubiquitin-proteasomeExpand