Alfred Krebs

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OBJECTIVES The processing of standard flexible cystoscopes is time-consuming and potentially hazardous to healthcare staff. We evaluated a novel flexible cystoscope system containing a disposable sheath, which obviates the need for chemical processing. METHODS A total of 100 patients undergoing office cystoscopy were randomized into a "sheath" or a(More)
PURPOSE We determined the efficacy and safety of flexible ureterorenoscopy for single intrarenal calculi and further stratified efficacy by stone burden. MATERIALS AND METHODS CROES collected prospective data on consecutive patients with urinary stones treated with ureterorenoscopy at 114 centers worldwide for 1 year. Only patients who underwent flexible(More)
A comparative enzyme analysis was performed on 3 pancreatic extracts generally used for dermal-epidermal separation, namely, crude trypsin (Difco), crude trypsin (Sigma) and pancreatin. A fourth pancreatic extract, crude lipase, was subjected to a corresponding analysis. The 4 extracts were assayed for activities of: protease (total), trypsin, chymotrypsin,(More)
Inflammation and irregular epidermal cell proliferation are characteristic features of psoriasis. Neutrophil accumulation, cutaneous vasodilatation, and increased blood flow are inflammatory components which have largely been attributed to a deranged arachidonic acid metabolism. Indeed, elevated amounts of lipoxygenase products, e.g., 5-HETE(More)
This study was aimed at investigating the role of the nerves in the pathomechanism of psoriasis. The structure of skin nerves of 10 patients with active psoriasis and of 6 healthy control persons has been studied by means of the microscope and the electron-microscope. Eight of the patients were subjected to punch biopsies of psoritatic plaques as well as(More)
A patient suffering from severe pemphigus vulgaris was treated using large-volume plasma exchange in combination with an immunosuppressive regimen. As some recent reports have shown evidence that polyclonal, polyspecific human IgG in high doses through the i.v. route (IGIV) protect target platelets in idiopathic thrombocytopenic purpura from attack by(More)
PURPOSE To characterize the flow of a novel ureteral stent composed of a nickel-cobalt-chromium-molybde-num alloy and compare it with flow in a standard ureteral stent. MATERIALS AND METHODS Six 6F Resonance stents and six 6F standard Black Beauty ureteral stents were placed in six Yucatan minipigs, with each pig serving as its own control. Flow(More)
OBJECTIVE To assess a prototype ureteric 'buoy' stent with a 10 F upper body tapering to a 3F tail, developed to potentially reduce stent-related irritative symptoms while providing an adequate mould for healing after endopyelotomy. MATERIALS AND METHODS Eighteen Yucatan minipigs had the stent placed either into the intact ureter (phase I) or after Acucise(More)
The apancreatic state secondary to resective surgery for chronic pancreatitis is associated with a high rate of late morbidity and mortality that is due, in part, to endocrine insufficiency. Resective procedures should, therefore, be used very selectively. Over the last 2 decades we have seen a shift from extensive distal resections to limited proximal(More)
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