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  • Alfred H. Schinkel, Jaap Jan J. Smit, Olaf van Tellingen, Jos H. Beijnen, Piet Borst
  • Medicine, Biology
  • Cell
  • 1994 (First Publication: 1 May 1994)
  • We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P-glycoprotein. The mice were viable and fertile and appeared phenotypicallyContinue Reading
  • John Douglas Allen, Arnold van Loevezijn, +6 authors Alfred H. Schinkel
  • Biology, Medicine
  • Molecular cancer therapeutics
  • 2002
  • Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics of substrateContinue Reading
  • Alfred H. Schinkel, Els Wagenaar, C A Mol, L van Deemter
  • Medicine
  • The Journal of clinical investigation
  • 1996 (First Publication: 1 June 1996)
  • The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its absence in mdr1a (-/-) mice leads to highly increased levels of the drugs ivermectin, vinblastine, digoxin, andContinue Reading
  • Johan W. Jonker, Marije Buitelaar, +9 authors Alfred H. Schinkel
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Publication: 12 November 2002)
  • The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. We show here that miceContinue Reading
  • Marc Maliepaard, George L. Scheffer, +6 authors Jan H.M. Schellens
  • Biology, Medicine
  • Cancer research
  • 2001 (First Publication: 15 April 2001)
  • High expression of the Breast Cancer Resistance Protein (BCRP) gene has been shown to be involved in resistance to chemotherapeutic drugs. Knowledge of the localization of BCRP protein in normalContinue Reading
  • Raymond Evers, Mirjam Kool, +8 authors Piet Borst
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1998 (First Publication: 1 April 1998)
  • The canalicular (apical) membrane of the hepatocyte contains an ATP-dependent transport system for organic anions, known as the multispecific organic anion transporter (cMOAT). The deduced amino acidContinue Reading
  • Jaap Jan J. Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink, Albert K. Groen, Piet Borst
  • Medicine, Biology
  • Cell
  • 1993 (First Publication: 1 November 1993)
  • Two types of P-glycoprotein have been found in mammals: the drug-transporting P-glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The latter is encoded by the humanContinue Reading
  • Alfred H. Schinkel, Erin Wagenaar, L van Deemter, C A Mol, Piet Borst
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1995 (First Publication: 1 October 1995)
  • We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a profound effect on the tissue distribution and elimination ofContinue Reading