Alfred C. Lane

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In the present studies the potency and selectivity of idazoxan (RX 781094) were compared with yohimbine and its diastereoisomers rauwolscine and corynanthine in both functional studies and radioligand binding experiments. Prejunctional α2- and postjunctional α1-adrenoceptor antagonist potencies were assessed by determining pA2 values against clonidine on(More)
Using three-colour flow cytometry, we have measured intracellular IL-2, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) induced in human CD4+ and CD8+ T cells from normal donors and patients with common variable immunodeficiency (CVID). Since a new range of directly FITC-conjugated anti-cytokine antibodies was used, conditions were(More)
We have investigated the antigenic modulation induced by a number of antibody fragments and derivatives directed against the idiotype of the surface Ig of the L2C guinea pig B lymphoblastic leukemia, and studied the effects upon such modulation of the simultaneous presence of cells expressing Fc gamma receptors (FcR). In vitro studies confirmed previous(More)
The infusion of anti-idiotypic antibody in patients with lymphoma has proved a relatively innocuous procedure, but in general had yielded only partial, short-lived remissions of disease. A major problem is that xenogeneic antibody is simply not well-fitted to destroying mammalian cells: complement and cellular effectors (K cells and phagocytes) are not(More)
In fo rmal i ty will be the keynote of t h e cotton dress and s h i f t .sleeve dunce Sa tu rday night which will climax the observance of Cotton Day on the cumpus. S tuden t s will be able to dance comfor tab ly in g ingham f rocks anil with open shir t -col lars a t the weekly dance Avhlch the commit tee has planned us a f ina le to the day annual ly des(More)