Alfred B. Knight

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STUDY OBJECTIVE To test the hypothesis that intraabdominal pressures (IAP) associated with abdominal insufflation for laparoscopic procedures can alter pulmonary and hemodynamic values in the pregnant baboon and hemodynamic values in the fetus. DESIGN A descriptive physiologic study. SETTING Animal research facility at Scott and White Memorial Hospital,(More)
Six patients were anaesthetized with 70% nitrous oxide in oxygen supplemented by infusion of propofol 40, 80, 120, 160 and 200 micrograms kg-1 min-1 sequentially in successive 10-min periods. Auditory evoked response (AER) and lower oesophageal contractility (LOC) were monitored. The AER findings were consistent with those noted in previous studies of i.v.(More)
BACKGROUND Hereditary angioedema (HAE) is an uncommon disorder of the complement system due to a deficiency or dysfunction of the inhibitor of the first component of complement (C1 INH). Clinically, HAE is characterized by episodic abdominal pain or edema of the extremities, face, larynx and vulva. Laryngeal edema is potentially lethal and accounts for(More)
Four cases are presented of maternal pulmonary edema occurring in patients who had no primary cardiac disease but who were receiving terbutaline and glucocorticoids or terbutaline alone for treatment of premature labor. Fluid overload was the event that triggered this decompensation. The physiologic high-output cardiac state of pregnancy is described and(More)
We report the presence of an immunoreactive digoxin-like substance in blood from third trimester pregnant women. The sera from 51 women in the third trimester of pregnancy were analyzed by 4 commercially available digoxin RIAs. None of these patients was receiving digoxin. Digoxin immunoreactivity was detected in all patients by 3 of 4 assays. The measured(More)
OBJECTIVE Although most methods for selecting the sex of offspring by sorting spermatozoa are ineffective at shifting the ratio of Y- to X-containing cells, some commercial sources continue to offer such services. Our objective was to evaluate commercially "sorted" samples with use of dual-color fluorescence in situ hybridization and to identify variations(More)
Embryo transfer is facilitated with ultrasound guidance. The 16 ultrasound-guided transfers were rated easier, and there was less catheter distortion, in comparison with 12 transfers guided by "clinical feel." The benefits we ascribe to ultrasound guidance are as follows: (1) transfers can be done with the patient supine in the lithotomy position; (2) the(More)
We have detected an endogenous digoxin-immunoreactive substance in the blood of third trimester pregnant women, of newborn infants and in amniotic fluids. In this report we present data showing an increase in blood levels of this endogenous substance in pregnant women with time of gestation (45 +/- 12, 125 +/- 32, and 195 +/- 27 pg/ml digoxin-equivalent for(More)
Seizure prophylaxis is standard intrapartum therapy for patients with pregnancy-induced hypertension. Magnesium sulfate is used in the United States in spite of limited literature comparing its efficacy with other anticonvulsants. Fifty patients with pregnancy-induced hypertension were prospectively randomized to receive magnesium sulfate or phenytoin for(More)