Alfred Böcking

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The paper describes the key component of the Multimodal Cell Analysis approach, a novel cytologic evaluation method for early cancer detection. The approach is based on repeated staining of a cell smear. The correlation of features and data extracted from the different stains, and related to relocated individual cells, may yield a dramatic increase of(More)
Cancer is one of the most common causes of death. Cytopathological, i.e., cell-based, diagnosis of cancer can be applied in screening scenarios and allows an early and highly sensitive detection of cancer, thus increasing the chance for cure. The detection of cancer on cells addressed in this paper is based on bright field light microscopy. The cells are(More)
Silver staining of cytopathologic specimens offers advantages in cancer diagnostics. A difficulty with such stained cell specimens is the very high dynamic range needed by the imaging system to appropriately cover the varying stain intensities. Beside those images of cell nuclei that can be used for the diagnostic interpretation, there are nuclei that(More)
The paper describes the key component of the Multimodal Cell Analysis approach, a novel cytologic evaluation method for early cancer detection. The approach is based on a repeated staining of a cell smear. The correlation of features and data extracted from different stainings, and related to relocated individual cells, will yield a dramatic increase of(More)
For successful cure, cancer has to be detected as early as possible. Since cancer starts from a single cell, this can best be done using cytopathological methods. One important diagnostically relevant measure is the proliferation rate of the cells, which can be estimated from segmented silver stained nuclei. However, the microscopy images of silver stained(More)
title = {{S}egmentation of {N}ucleolar {O}rganizer {R}egions by {M}eans of {H}igh {D}ynamic {R}ange {C}ell {I}maging and {A}nalysis}, Abstract Active nucleolar organizer regions (NORs) are affine to silver (Ag) and therefore visible in silver stained cell specimens. These so called AgNORs are of diagnostic relevance for early cancer diagnosis. Therefore we(More)
The potential of cytopathologic diagnoses to detect cancer of a variety of types non-invasively, cost-efficiently and up to three years ahead of conventional histopathologic diagnoses can be increased by the application of adjuvant methods, i.e. the combination of different stainings. For further improvement of cytopathology we introduced multimodal cell(More)