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The programmed cell death inducing effect of the EGF receptor tyrosine kinase inhibitor alpha-cyano-3,4-dihydroxycinnamthioamide (AG213) was investigated in vitro on HT-29 human colon tumor. AG213 at concentrations between 45 to 450 microM blocks the proliferation of HT-29 cells. Morphological findings suggest that the selective tyrosine kinase inhibitor(More)
BACKGROUND Where people die can influence a number of indicators of the quality of dying. We aimed to describe the place of death of people with cancer and its associations with clinical, socio-demographic and healthcare supply characteristics in 14 countries. METHODS Cross-sectional study using death certificate data for all deaths from cancer (ICD-10(More)
LH-RH analogs cause some inhibition of growth of pancreatic cancers. Syrian golden hamsters bearing chemically induced pancreatic cancers were treated with [D-Trp6]LH-RH for 3 d before sacrifice. LH-RH receptors were localized by electron-microscopic immunohistochemistry in the tumor cells of both treated and untreated hamsters. [D-Trp6]LH-RH treatment(More)
A well-organized platoon control may have advantages in terms of increasing highway capacity and decreasing fuel consumption and emissions. The paper proposes the design of the velocity of platoon. In the velocity design several factors must be taken into consideration such as fuel consumption, road inclinations, emissions and traveling time. Since the(More)
Previous work showed that hamster and human pancreatic tumors but not normal pancreata exhibit low-affinity cell-membrane receptors for luteinizing hormone-releasing hormone (LHRH). Although the regression of experimental pancreatic cancers induced by treatment with LHRH agonists or antagonists could be explained in part by the creation of sex-steroid(More)
In this work a novel controller design method is suggested for motorway shockwave management using ramp metering and variable speed limit (VSL) control. The proposed controller has a feedforward-feedback control structure that is designed for a motorway arterial model. For the feedback design the nonlinear model predictive control is used. The feedforward(More)
The paper proposes a traffic speed prediction algorithm for urban road traffic networks. The motivation of the prediction is to provide short time forecast in order to support ITS (Intelligent Transport System) functionalities, such as traveler information systems, route guidance (navigation) systems, as well as adaptive traffic control systems. A potential(More)