Alfonso Varela-Román

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Knowledge of the role of the soluble receptor for advanced glycation end products (sRAGEs) in chronic heart failure (CHF) is very limited. In the present study, we measured plasma sRAGE levels in patients with CHF and examined whether plasma sRAGE predicts prognosis in patients with HF independently of validated scores as the Seattle Heart Failure Score(More)
OBJECTIVES To determine clinical and prognostic differences between preserved and deteriorated systolic function (defined as left ventricular (LV) ejection fractions > or = 50% and < 50%, respectively) in patients with heart failure satisfying modified Framingham criteria. PATIENTS AND METHODS Records were studied of 1252 patients with congestive heart(More)
BACKGROUND Inflammation and nutritional state are involved in the pathogenesis of heart failure (HF). OBJECTIVE To study the contribution of alpha-1-acid-glycoprotein (AGP) to these factors and its prognostic value in acute (AHF) or chronic HF (CHF). METHODS The observational study has included 147 patients (mean age 70years, 62% men) admitted to a(More)
BACKGROUND Recent studies suggested that advanced glycation end-products (AGEs) and their receptor (RAGE) interaction may be promoted by inflammation and oxidative stress. These processes could also contribute to the pathogenesis of atrial fibrillation (AF), but their roles remain poorly defined. We studied the association of AGE-RAGE axis with AF in(More)
AIMS Knowledge of the role of advanced glycation end products (AGE), their receptor (RAGE), and the receptor's soluble form (sRAGE), in heart failure (HF) is very limited. We evaluated the clinical role of the AGE-RAGE system in HF and in particular any association it might have with ischaemic aetiology. METHODS AND RESULTS We measured fluorescent AGE,(More)
AIM To investigate the influence of diabetes mellitus (DM) on the prognosis of heart failure (HF) patients, focussing specifically on aetiology and patients with preserved left ventricular systolic function (LVSF), which to date has not been fully investigated. METHOD AND RESULTS 1659 Patients hospitalized for HF between 1991 and 2002 in the Cardiology(More)
BACKGROUND Despite encouraging declines in the incidence of heart failure (HF) complicating acute coronary syndrome (ACS), it remains a common problem with high mortality. Being able to identify patients at high risk of HF after ACS would have great clinical and economic impact. With this study, we assessed the usefulness of the GRACE score to predict HF(More)
OBJECTIVE To determine the clinical and prognostic differences between patients with heart failure who had preserved or deteriorated systolic function, defined as a left ventricular ejection fraction of > 50% or < 50%, respectively, within two weeks of admission to hospital. METHODS The records of 229 patients with congestive heart failure were studied.(More)
OBJECTIVE Characterization of current morbidity and mortality among heart failure (HF) outpatients in Galicia (N.W. Spain), together with their main determinants. DESIGN Prospective multicentre study involving 149 primary care physicians. SETTING Primary care physicians selected randomly from among all (1959) primary care physicians in Galicia. (More)
BACKGROUND AND OBJECTIVES Advanced glycation end-products (AGE) are implicated in the physiopathology and prognosis of heart failure (HF) and they accumulate in situations such as kidney failure (KF). Our objective was to analyze the relation between AGE and KF in patients with chronic HF. MATERIALS AND METHODS 102 consecutive patients of our medical(More)